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Slack / Private Message Drop, p.1027 [SLACK_001241] · slack_pm:msg:10728

Date: 2021-11-24 08:54
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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Yeah, very clearly not a conscious choice - just nature doing it's thing. All it took was a virus with a landing site and then stuff comes and goes around that site all the time - just had to be the right sequence that popped in.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-11-24 08:52 Robert F. Garry open

Not without having all the knowledge in hindsight.
2021-11-24 08:52 Andrew Rambaut open

Fair enough. I won't tweet that then.
2021-11-24 08:52 Robert F. Garry open

Same argument with the O-linked glycans - without having SC2 as the guidepost - you would not know....
2021-11-24 08:53 Robert F. Garry open

Good - that would just encourage the Leakers...
2021-11-24 08:54 Kristian G. Andersen

Yeah, very clearly not a conscious choice - just nature doing it's thing. All it took was a virus with a landing site and then stuff comes and goes around that site all the time - just had to be the right sequence that popped in.
2021-11-24 08:55 Robert F. Garry open

Yup - nature - we get to see the brilliance but only afterwards.
2021-11-24 09:02 Kristian G. Andersen open

Some alignments with these sequences combined with relevant SARSr-CoVs - just FYI. [shared file(s): 2021.11.24_alignment_spike_nt.geneious, 2021.11.24_alignment_spike_aa.geneious, 2021.11.24_alignment_spike_aa_minimal_annotated.geneious]
2021-11-24 09:03 Kristian G. Andersen open

This is mind blowing - BANAL-52 is closer to Hu-1 in the spike (in AA space) than the Botswana sequences are.... Holy fuck.
2021-11-24 09:04 Kristian G. Andersen open

98.4% vs 96.9%

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