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Slack / Private Message Drop, p.1026 [SLACK_001240] · slack_pm:msg:10722

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I've think that the enzymes that do the cleavage at R/S also probably benefit by having a "landing pad."

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2021-11-24 08:45 Andrew Rambaut open

The RmYN02-like are quite distant to SC2 in this bit of the genome. Is it not more interesting that RaTG13/BANAL-20-52-like viruses acquired the QTQT motif?
2021-11-24 08:46 Kristian G. Andersen open

Yup - almost looks step-wise.
2021-11-24 08:46 Robert F. Garry open

Indeed - that's always puzzled me.
2021-11-24 08:48 Andrew Rambaut open

What would it do without the PRRA insert?
2021-11-24 08:48 Robert F. Garry

I've think that the enzymes that do the cleavage at R/S also probably benefit by having a "landing pad."
2021-11-24 08:50 Andrew Rambaut open

So if you were going to pick a virus from amongst your large bank of samples in which to try popping a FCS insertion you would pick out one with QTQT?
2021-11-24 08:52 Robert F. Garry open

Not without having all the knowledge in hindsight.
2021-11-24 08:52 Andrew Rambaut open

Fair enough. I won't tweet that then.
2021-11-24 08:52 Robert F. Garry open

Same argument with the O-linked glycans - without having SC2 as the guidepost - you would not know....