Slack / Private Message Drop — page 1026

[2021-11-24 08:42:32] [Andrew Rambaut] [thread - ID: 2021-11-24 08:42:32] I assume you say it cutie-cutie? [2021-11-24 08:42:37] [Kristian Andersen] I had missed that previously, but that's actually kinda interesting - because: [shared file(s): furin_aa_nov21.png] [2021-11-24 08:43:15] [Kristian Andersen] For the non-SC2 viruses they _either_ have QTQT _or_ the indel - but not both. SC2 has both. [2021-11-24 08:45:17] [Andrew Rambaut] The RmYN02-like are quite distant to SC2 in this bit of the genome. Is it not more interesting that RaTG13/BANAL-20-52-like viruses acquired the QTQT motif? [2021-11-24 08:46:41] [Kristian Andersen] Yup - almost looks step-wise. [2021-11-24 08:46:56] [Robert Garry] Indeed - that's always puzzled me. [2021-11-24 08:48:04] [Andrew Rambaut] What would it do without the PRRA insert? [2021-11-24 08:48:13] [Robert Garry] I've think that the enzymes that do the cleavage at R/S also probably benefit by having a "landing pad." [2021-11-24 08:50:03] [Andrew Rambaut] So if you were going to pick a virus from amongst your large bank of samples in which to try popping a FCS insertion you would pick out one with QTQT? [2021-11-24 08:52:16] [Robert Garry] Not without having all the knowledge in hindsight. [2021-11-24 08:52:52] [Andrew Rambaut] Fair enough. I won't tweet that then. [2021-11-24 08:52:59] [Robert Garry] Same argument with the O-linked glycans - without having SC2 as the guidepost - you would not know.... [2021-11-24 08:53:53] [Robert Garry] Good - that would just encourage the Leakers...