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Slack / Private Message Drop, p.1027 [SLACK_001241] · slack_pm:msg:10729

Page text: p.1027 · original PDF

Date
2021-11-24 08:55
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry

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Yup - nature - we get to see the brilliance but only afterwards.

In context

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  1. 2021-11-24 08:52 Andrew Rambaut open
    Fair enough. I won't tweet that then.
  2. 2021-11-24 08:52 Robert F. Garry open
    Same argument with the O-linked glycans - without having SC2 as the guidepost - you would not know....
  3. 2021-11-24 08:53 Robert F. Garry open
    Good - that would just encourage the Leakers...
  4. 2021-11-24 08:54 Kristian G. Andersen open
    Yeah, very clearly not a conscious choice - just nature doing it's thing. All it took was a virus with a landing site and then stuff comes and goes around that site all the time - just had to be the right sequence that popped in.
  5. 2021-11-24 08:55 Robert F. Garry
    Yup - nature - we get to see the brilliance but only afterwards.
  6. 2021-11-24 09:02 Kristian G. Andersen open
    Some alignments with these sequences combined with relevant SARSr-CoVs - just FYI. [shared file(s): 2021.11.24_alignment_spike_nt.geneious, 2021.11.24_alignment_spike_aa.geneious, 2021.11.24_alignment_spike_aa_minimal_annotated.geneious]
  7. 2021-11-24 09:03 Kristian G. Andersen open
    This is mind blowing - BANAL-52 is closer to Hu-1 in the spike (in AA space) than the Botswana sequences are.... Holy fuck.
  8. 2021-11-24 09:04 Kristian G. Andersen open
    98.4% vs 96.9%
  9. 2021-11-24 09:10 Robert F. Garry open
    Yeah - what I really want to do is put the PRRA into BANAL-52 and see how it does several species.

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