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Slack / Private Message Drop, p.1026 [SLACK_001240] · slack_pm:msg:10718

Date: 2021-11-24 08:45
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

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The RmYN02-like are quite distant to SC2 in this bit of the genome. Is it not more interesting that RaTG13/BANAL-20-52-like viruses acquired the QTQT motif?

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-11-24 08:40 Robert F. Garry open

yes both are neutral polar animo acids
2021-11-24 08:42 Andrew Rambaut open

I assume you say it cutie-cutie?
2021-11-24 08:42 Kristian G. Andersen open

I had missed that previously, but that's actually kinda interesting - because: [shared file(s): furin_aa_nov21.png]
2021-11-24 08:43 Kristian G. Andersen open

For the non-SC2 viruses they _either_ have QTQT _or_ the indel - but not both. SC2 has both.
2021-11-24 08:45 Andrew Rambaut

The RmYN02-like are quite distant to SC2 in this bit of the genome. Is it not more interesting that RaTG13/BANAL-20-52-like viruses acquired the QTQT motif?
2021-11-24 08:46 Kristian G. Andersen open

Yup - almost looks step-wise.
2021-11-24 08:46 Robert F. Garry open

Indeed - that's always puzzled me.
2021-11-24 08:48 Andrew Rambaut open

What would it do without the PRRA insert?
2021-11-24 08:48 Robert F. Garry open

I've think that the enzymes that do the cleavage at R/S also probably benefit by having a "landing pad."

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