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Slack / Private Message Drop, p.1026 [SLACK_001240] · slack_pm:msg:10720

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Indeed - that's always puzzled me.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-11-24 08:42 Kristian G. Andersen open

I had missed that previously, but that's actually kinda interesting - because: [shared file(s): furin_aa_nov21.png]
2021-11-24 08:43 Kristian G. Andersen open

For the non-SC2 viruses they _either_ have QTQT _or_ the indel - but not both. SC2 has both.
2021-11-24 08:45 Andrew Rambaut open

The RmYN02-like are quite distant to SC2 in this bit of the genome. Is it not more interesting that RaTG13/BANAL-20-52-like viruses acquired the QTQT motif?
2021-11-24 08:46 Kristian G. Andersen open

Yup - almost looks step-wise.
2021-11-24 08:46 Robert F. Garry

Indeed - that's always puzzled me.
2021-11-24 08:48 Andrew Rambaut open

What would it do without the PRRA insert?
2021-11-24 08:48 Robert F. Garry open

I've think that the enzymes that do the cleavage at R/S also probably benefit by having a "landing pad."
2021-11-24 08:50 Andrew Rambaut open

So if you were going to pick a virus from amongst your large bank of samples in which to try popping a FCS insertion you would pick out one with QTQT?
2021-11-24 08:52 Robert F. Garry open

Not without having all the knowledge in hindsight.