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Slack / Private Message Drop, p.757 [SLACK_000971] · slack_pm:msg:07932

Date: 2021-05-06 20:52
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes

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And it shows the key point: you use a standard backbone when you do this GOF work. And surely Shi would have done the same as she collaborated with Baric? And surely she would have asked Baric for advice but there's nothing in his emails?

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2021-05-06 20:40 Edward C. Holmes open

Quickly on Wade: pretty amazing that he accuses us of bad science when he ignores ALL the counter data.
2021-05-06 20:41 Kristian G. Andersen open

Yup. I expect RelBloom will do the same.
2021-05-06 20:42 Kristian G. Andersen open

When it comes to Baric fiddling with viruses, this, of course, is the mother of all papers... https://www.nature.com/articles/s41591-020-0924-2
2021-05-06 20:42 Kristian G. Andersen open

Well, this https://www.nature.com/articles/nm.3985
2021-05-06 20:52 Edward C. Holmes

And it shows the key point: you use a standard backbone when you do this GOF work. And surely Shi would have done the same as she collaborated with Baric? And surely she would have asked Baric for advice but there's nothing in his emails?
2021-05-06 20:55 Kristian G. Andersen open

Yup. Exactly.
2021-05-06 20:55 Edward C. Holmes open

First experiment to stick the SC2 RBD in a mouse adapted strain.
2021-05-06 20:57 Kristian G. Andersen open

Yeah - very likely, but depends on the purpose of the experiment.
2021-05-06 21:08 Kristian G. Andersen open

And just for reference - here are those beautiful feline CoVs with an identical FCS motif. It's out there... [shared file(s): Screen Shot 2021-05-06 at 9.07.11 PM.png]

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