A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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What's critically important here - drop in efficacy, even bigger than drop observed in vitro
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(which is not surprising to me)
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But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without
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I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this?
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2021-02-07 12:33
Robert F. Garry
Good question - they really should have sequence data in the breakthrus -
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> But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without Ah, yes, good point - I assumed with all those, but yeah, they're not all fixed. I assume likely all three > I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this? Not stabilized - like Sputnik. Why they did that, I don't know. Why they haven't updated it, I don't know. Fact is, in six months, that vaccine will be totally irrelevant.
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I'm additionally worried that South Africa might have additional data on this vaccine we don't know about - they justcanceled their whole vaccine program with this one and that's a HUGE step you don't take lightly unless there are additional concern (?). We have to remember that shit immunity can often be worse than no immunity.
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Bob, I will take a look when I can but I would just hold off submitting anything until after the WHO team have made their announcement in a few days. I sense that Daszak is increasingly bullish about excluding WIV.