Chat message

Slack / Private Message Drop, p.496 [SLACK_000710] · slack_pm:msg:05181

Date: 2021-02-07 12:35
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Vaccines

Recipients on this medium are inferred from channel membership, not per-message addressing.

> But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without Ah, yes, good point - I assumed with all those, but yeah, they're not all fixed. I assume likely all three > I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this? Not stabilized - like Sputnik. Why they did that, I don't know. Why they haven't updated it, I don't know. Fact is, in six months, that vaccine will be totally irrelevant.

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
I assume likely all three > I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this?	needs context	uncertain explicit hedge	questions
Fact is, in six months, that vaccine will be totally irrelevant.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

I assume likely all three > I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this?

needs context

uncertain explicit hedge

questions

Fact is, in six months, that vaccine will be totally irrelevant.

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-02-07 12:31 Kristian G. Andersen open

(which is not surprising to me)
2021-02-07 12:31 Andrew Rambaut open

But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without
2021-02-07 12:32 Robert F. Garry open

I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this?
2021-02-07 12:33 Robert F. Garry open

Good question - they really should have sequence data in the breakthrus -
2021-02-07 12:35 Kristian G. Andersen

> But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without Ah, yes, good point - I assumed with all those, but yeah, they're not all fixed. I assume likely all three > I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this? Not stabilized - like Sputnik. Why they did that, I don't know. Why they haven't updated it, I don't know. Fact is, in six months, that vaccine will be totally irrelevant.
2021-02-07 12:36 Kristian G. Andersen open

I'm additionally worried that South Africa might have additional data on this vaccine we don't know about - they justcanceled their whole vaccine program with this one and that's a HUGE step you don't take lightly unless there are additional concern (?). We have to remember that shit immunity can often be worse than no immunity.
2021-02-07 13:10 Edward C. Holmes open

Bob, I will take a look when I can but I would just hold off submitting anything until after the WHO team have made their announcement in a few days. I sense that Daszak is increasingly bullish about excluding WIV.

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