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Slack / Private Message Drop, p.496 [SLACK_000710] · slack_pm:msg:05176

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What's critically important here - drop in efficacy, even bigger than drop observed in vitro

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2021-02-07 12:29 Andrew Rambaut open

When testing vaccines against B.1.351, are they using one with Leif and Karen?
2021-02-07 12:29 Andrew Rambaut open

Or the serum - do they know the genotype of the donor?
2021-02-07 12:30 Robert F. Garry open

https://docs.google.com/document/d/17-2hi7-fNsjE44himeCkm1PoZ7_-ncvpxUlhShZzDCU/edit On another note - I just popped a *nearly clean draft* of a proposed Virological post about Cambodian, Thai and Japanese bat sarbecoviruses. It's actually pretty mild, but Alina etc. *do* get attention. I borrowed VERY heavily from this channel,so please let me know if you are co-authors or I can go solo...
2021-02-07 12:30 Kristian G. Andersen open

These are clinical trials - so wildtype
2021-02-07 12:31 Kristian G. Andersen

What's critically important here - drop in efficacy, even bigger than drop observed in vitro
2021-02-07 12:31 Kristian G. Andersen open

(which is not surprising to me)
2021-02-07 12:31 Andrew Rambaut open

But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without
2021-02-07 12:32 Robert F. Garry open

I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this?
2021-02-07 12:33 Robert F. Garry open

Good question - they really should have sequence data in the breakthrus -