A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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https://docs.google.com/document/d/17-2hi7-fNsjE44himeCkm1PoZ7_-ncvpxUlhShZzDCU/edit On another note - I just popped a *nearly clean draft* of a proposed Virological post about Cambodian, Thai and Japanese bat sarbecoviruses. It's actually pretty mild, but Alina etc. *do* get attention. I borrowed VERY heavily from this channel,so please let me know if you are co-authors or I can go solo...
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These are clinical trials - so wildtype
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What's critically important here - drop in efficacy, even bigger than drop observed in vitro
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(which is not surprising to me)
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2021-02-07 12:31
Andrew Rambaut
But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without
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I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this?
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Good question - they really should have sequence data in the breakthrus -
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> But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without Ah, yes, good point - I assumed with all those, but yeah, they're not all fixed. I assume likely all three > I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this? Not stabilized - like Sputnik. Why they did that, I don't know. Why they haven't updated it, I don't know. Fact is, in six months, that vaccine will be totally irrelevant.
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I'm additionally worried that South Africa might have additional data on this vaccine we don't know about - they justcanceled their whole vaccine program with this one and that's a HUGE step you don't take lightly unless there are additional concern (?). We have to remember that shit immunity can often be worse than no immunity.