Chat message

Slack / Private Message Drop, p.496 [SLACK_000710] · slack_pm:msg:05182

Date: 2021-02-07 12:36
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Vaccines

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I'm additionally worried that South Africa might have additional data on this vaccine we don't know about - they justcanceled their whole vaccine program with this one and that's a HUGE step you don't take lightly unless there are additional concern (?). We have to remember that shit immunity can often be worse than no immunity.

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Statement	Grade	Attribution	Stance
I'm additionally worried that South Africa might have additional data on this vaccine we don't know about - they justcanceled their whole vaccine program with this one and that's a HUGE step you don't take lightly unless there are additional concern (?).	needs context	uncertain explicit hedge	asserts

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needs context

uncertain explicit hedge

asserts

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2021-02-07 12:31 Andrew Rambaut open

But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without
2021-02-07 12:32 Robert F. Garry open

I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this?
2021-02-07 12:33 Robert F. Garry open

Good question - they really should have sequence data in the breakthrus -
2021-02-07 12:35 Kristian G. Andersen open

> But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without Ah, yes, good point - I assumed with all those, but yeah, they're not all fixed. I assume likely all three > I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this? Not stabilized - like Sputnik. Why they did that, I don't know. Why they haven't updated it, I don't know. Fact is, in six months, that vaccine will be totally irrelevant.
2021-02-07 12:36 Kristian G. Andersen

I'm additionally worried that South Africa might have additional data on this vaccine we don't know about - they justcanceled their whole vaccine program with this one and that's a HUGE step you don't take lightly unless there are additional concern (?). We have to remember that shit immunity can often be worse than no immunity.
2021-02-07 13:10 Edward C. Holmes open

Bob, I will take a look when I can but I would just hold off submitting anything until after the WHO team have made their announcement in a few days. I sense that Daszak is increasingly bullish about excluding WIV.

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