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Slack / Private Message Drop, p.496 [SLACK_000710] · slack_pm:msg:05177

Page text: p.496 · original PDF

Date
2021-02-07 12:31
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

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(which is not surprising to me)

In context

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  1. 2021-02-07 12:29 Andrew Rambaut open
    Or the serum - do they know the genotype of the donor?
  2. 2021-02-07 12:30 Robert F. Garry open
    https://docs.google.com/document/d/17-2hi7-fNsjE44himeCkm1PoZ7_-ncvpxUlhShZzDCU/edit On another note - I just popped a *nearly clean draft* of a proposed Virological post about Cambodian, Thai and Japanese bat sarbecoviruses. It's actually pretty mild, but Alina etc. *do* get attention. I borrowed VERY heavily from this channel,so please let me know if you are co-authors or I can go solo...
  3. 2021-02-07 12:30 Kristian G. Andersen open
    These are clinical trials - so wildtype
  4. 2021-02-07 12:31 Kristian G. Andersen open
    What's critically important here - drop in efficacy, even bigger than drop observed in vitro
  5. 2021-02-07 12:31 Kristian G. Andersen
    (which is not surprising to me)
  6. 2021-02-07 12:31 Andrew Rambaut open
    But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without
  7. 2021-02-07 12:32 Robert F. Garry open
    I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this?
  8. 2021-02-07 12:33 Robert F. Garry open
    Good question - they really should have sequence data in the breakthrus -
  9. 2021-02-07 12:35 Kristian G. Andersen open
    > But do they know whether the infected cases are with a B.1.351 with Leif and/or Karen or one without Ah, yes, good point - I assumed with all those, but yeah, they're not all fixed. I assume likely all three > I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this? Not stabilized - like Sputnik. Why they did that, I don't know. Why they haven't updated it, I don't know. Fact is, in six months, that vaccine will be totally irrelevant.

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