Chat message

Slack / Private Message Drop, p.496 [SLACK_000710] · slack_pm:msg:05172

Date: 2021-02-07 12:29
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut
Topics: Vaccines

Recipients on this medium are inferred from channel membership, not per-message addressing.

When testing vaccines against B.1.351, are they using one with Leif and Karen?

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
When testing vaccines against B.1.351, are they using one with Leif and Karen?	needs context	speaker_own	questions

Statement

Grade

Attribution

Stance

When testing vaccines against B.1.351, are they using one with Leif and Karen?

needs context

speaker_own

questions

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-02-07 12:23 Robert F. Garry open

Also mild-moderate disease - more important how about severe?
2021-02-07 12:25 Kristian G. Andersen open

I think Leif and Karen are key too - but I'd expect B.1.1.7 + Erik to come with a big hit too.
2021-02-07 12:26 Kristian G. Andersen open

Absolutely no effect preventing mild-moderate so I don't expect much ability to prevent severe either. But we'll see -this is very early data. It's just a shit vaccine - I'm sure the others won't see this bad a drop (and we have _some_ data on that) and will also prevent severe disease in many cases.
2021-02-07 12:28 Andrew Rambaut open

Leif is everywhere (and quite common on B.1.1.7)
2021-02-07 12:29 Andrew Rambaut

When testing vaccines against B.1.351, are they using one with Leif and Karen?
2021-02-07 12:29 Andrew Rambaut open

Or the serum - do they know the genotype of the donor?
2021-02-07 12:30 Robert F. Garry open

https://docs.google.com/document/d/17-2hi7-fNsjE44himeCkm1PoZ7_-ncvpxUlhShZzDCU/edit On another note - I just popped a *nearly clean draft* of a proposed Virological post about Cambodian, Thai and Japanese bat sarbecoviruses. It's actually pretty mild, but Alina etc. *do* get attention. I borrowed VERY heavily from this channel,so please let me know if you are co-authors or I can go solo...
2021-02-07 12:30 Kristian G. Andersen open

These are clinical trials - so wildtype
2021-02-07 12:31 Kristian G. Andersen open

What's critically important here - drop in efficacy, even bigger than drop observed in vitro

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