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Slack / Private Message Drop, p.415 [SLACK_000629] · slack_pm:msg:04292

Date: 2021-01-18 08:15
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

Recipients on this medium are inferred from channel membership, not per-message addressing.

Eek + Pooh: ```Accession ID Collection date Submission date Location EPI_ISL_778908 2020-11-30 2021-01-07 North America / USA / Maryland EPI_ISL_791414 2020-11-21 2021-01-08 North America / USA / Maryland EPI_ISL_791426 2020-12-30 2021-01-08 North America / USA / Maryland EPI_ISL_791427 2021-01-01 2021-01-08 North America / USA / Maryland```

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-18 07:20 Kristian G. Andersen open

Now I'm getting concerned. [shared file(s): Image from iOS.jpg]
2021-01-18 07:44 Robert F. Garry open

Actually the Gupta data fell about where I expected. 3-6 fold reduction is not fantastic for B117, but actually could have been worse. EeeK will likely result in a bigger drop I suspect.
2021-01-18 08:00 Kristian G. Andersen open

Yeah, I agree Bob. - right where you might expect it to land. Quite a number of folks with no neuts to either virus aswell. Eeek will for sure be worse and cross the 4x threshold (I believe) is being used in the flu field to trigger avaccine update.
2021-01-18 08:14 Robert F. Garry open

That's a good analogy to flu - and you're right vaccine update will be needed. Just hoping that most humans can mount a good response to K484.
2021-01-18 08:15 Andrew Rambaut

Eek + Pooh: ```Accession ID Collection date Submission date Location EPI_ISL_778908 2020-11-30 2021-01-07 North America / USA / Maryland EPI_ISL_791414 2020-11-21 2021-01-08 North America / USA / Maryland EPI_ISL_791426 2020-12-30 2021-01-08 North America / USA / Maryland EPI_ISL_791427 2021-01-01 2021-01-08 North America / USA / Maryland```
2021-01-18 08:18 Kristian G. Andersen open

Are they hanging with Nelly too?
2021-01-18 08:19 Andrew Rambaut open

No. Unrelated
2021-01-18 08:22 Kristian G. Andersen open

Interesting. I expect we'll see N501Y pop up on that background shortly.
2021-01-18 08:24 Kristian G. Andersen open

Bob, to your point about vaccine updates - yes, absolutely going to be needed. However, what's going to be very different here is that we're going to have a gazillion different (partially) vaccine 'resistant' lineages floating around atthe same time because we have sooooo many infections. Are we going to make an updated vaccine for each? Stick'em all together in a single vaccine? How are we going to prioritize?Until we use NPIs to massively drop infections down, I don't think we'll be successful in this game of whack-a-mole.

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