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Slack / Private Message Drop, p.380 [SLACK_000594] · slack_pm:msg:03953

Page text: p.380 · original PDF

Date
2021-01-11 13:59
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker
Edward C. Holmes

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:bomb:

In context

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  1. 2021-01-11 13:59 Andrew Rambaut open
    It seems like all of these lineages are converging to the same set of mutations
  2. 2021-01-11 13:59 Edward C. Holmes open
    I hope Tulio gets talking combining classification schemes - that will make a fun 7 hours.
  3. 2021-01-11 13:59 Andrew Rambaut open
    Oli will keep him right
  4. 2021-01-11 13:59 Robert F. Garry open
    https://www.fox10phoenix.com/news/fda-to-weigh-half-dosing-moderna-covid-19-vaccines-operation-warp-speed-of ficial-says "These are all reasonable questions to consider and evaluate in clinical trials," the FDA said in a statement on Monday." I agree that the UK dosing strategy is wrong - half dosing makes much more sense with both the prime and the boast. The half and third dosing was already considered in a clinical trial - Moderna's Phase Itrial. Two doses of 10 ug gave essentially the same neut and binding as two doses of 30 ug dose. One dose of 100was terrible and caused al ot more adverse reactions so tjhey stopped it. Hate to be cynical, but I think Moderna isprotecting it's newly hatched golden goose.
  5. 2021-01-11 13:59 Edward C. Holmes
    :bomb:
  6. 2021-01-11 14:07 Robert F. Garry open
    "It seems like all of these lineages are converging to the same set of mutations." Agree - Spike is covered with glycan - there are only a few places where antibodies can slip in - Eeek and the NTD mutations are in those spots. Once this virus got a furin cleavage site it opened up the possibility for Doug and its 613 twins to destabilzed thetrimers so you could get surface entry. The furin cleavage site is continuing to optimize itself possibly in epistasiswith Doug.
  7. 2021-01-11 14:41 Andrew Rambaut open
    The Japanese/Manaus cluster has the same nsp6 deletion that the UK and South African lineages have
  8. 2021-01-11 14:43 Edward C. Holmes open
    Wowser. That's not chance.
  9. 2021-01-11 14:51 Robert F. Garry open
    Places where the polymerase has tendency to slip and skip?

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