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Slack / Private Message Drop, p.184 [SLACK_000398] · slack_pm:msg:01898

Page text: p.184 · original PDF

Date
2020-09-18 16:18
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

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Yeah, RmYN02 - the more complete of the two genomes. Definitely another genome in there

In context

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  1. 2020-09-18 16:02 Kristian G. Andersen open
    I SO hoped some of these intrahost mutations near the RBD or the FCS, but sadly no. Would have been cool!
  2. 2020-09-18 16:08 Edward C. Holmes open
    You mean RmYN01? Yes, I've been asking Weifeng to get some analysis done on that for ages.
  3. 2020-09-18 16:10 Edward C. Holmes open
    I think he said he only had an incomplete genome, including the RdRp, although even though that would be really interesting.
  4. 2020-09-18 16:11 Edward C. Holmes open
    Sorry, you mean in the RmYN02 reads? I seem to remember Weifeng discussing that before. Might even be noted in the paper. Can't remember. RmYN02 is pooled from a number of bats - 11 or 13, I can't quite recall.
  5. 2020-09-18 16:18 Kristian G. Andersen
    Yeah, RmYN02 - the more complete of the two genomes. Definitely another genome in there
  6. 2020-09-18 16:20 Kristian G. Andersen open
    It's another bat CoV closely related (but not identical) to others previously sequenced. Every yellow bar is an intrahost variant >10% (SNPs are all linked as far as I can tell, so I think it's just one additional genome) [shared file(s): Screen Shot 2020-09-18 at 16.19.28.png]
  7. 2020-09-18 16:25 Edward C. Holmes open
    Yes, I agree. I'll check back what we did - if anything - about this. It would be really interesting to see a phylogeny with that, RmYN02 and RmYN01 included.
  8. 2020-09-18 16:37 Kristian G. Andersen open
    I'm just going to pull that minority genome out - I'll keep you posted... Yeah, this is very interesting
  9. 2020-09-18 16:39 Edward C. Holmes open
    Great!

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