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Slack / Private Message Drop, p.183 [SLACK_000397] · slack_pm:msg:01894

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I SO hoped some of these intrahost mutations near the RBD or the FCS, but sadly no. Would have been cool!

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-09-18 15:22 Edward C. Holmes open

Yan is the fantasist. Alina has just lost it.
2020-09-18 15:39 Kristian G. Andersen open

Here's what I'm assembling - missing anything? [shared file(s): Screen Shot 2020-09-18 at 15.39.27.png]
2020-09-18 15:40 Kristian G. Andersen open

MP789 is the same(ish) as the one that was initially reported on virological
2020-09-18 15:58 Kristian G. Andersen open

Pretty interesting. Looking at RmYN02 the consensus is totally solid, however, I actually think there's another closely related bat CoV in there at a ~15% frequency. I'll dig a little deeper, but Tommy might be interested in looking at that
2020-09-18 16:02 Kristian G. Andersen

I SO hoped some of these intrahost mutations near the RBD or the FCS, but sadly no. Would have been cool!
2020-09-18 16:08 Edward C. Holmes open

You mean RmYN01? Yes, I've been asking Weifeng to get some analysis done on that for ages.
2020-09-18 16:10 Edward C. Holmes open

I think he said he only had an incomplete genome, including the RdRp, although even though that would be really interesting.
2020-09-18 16:11 Edward C. Holmes open

Sorry, you mean in the RmYN02 reads? I seem to remember Weifeng discussing that before. Might even be noted in the paper. Can't remember. RmYN02 is pooled from a number of bats - 11 or 13, I can't quite recall.
2020-09-18 16:18 Kristian G. Andersen open

Yeah, RmYN02 - the more complete of the two genomes. Definitely another genome in there