A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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Here's what I'm assembling - missing anything? [shared file(s): Screen Shot 2020-09-18 at 15.39.27.png]
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MP789 is the same(ish) as the one that was initially reported on virological
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Pretty interesting. Looking at RmYN02 the consensus is totally solid, however, I actually think there's another closely related bat CoV in there at a ~15% frequency. I'll dig a little deeper, but Tommy might be interested in looking at that
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I SO hoped some of these intrahost mutations near the RBD or the FCS, but sadly no. Would have been cool!
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2020-09-18 16:08
Edward C. Holmes
You mean RmYN01? Yes, I've been asking Weifeng to get some analysis done on that for ages.
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I think he said he only had an incomplete genome, including the RdRp, although even though that would be really interesting.
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Sorry, you mean in the RmYN02 reads? I seem to remember Weifeng discussing that before. Might even be noted in the paper. Can't remember. RmYN02 is pooled from a number of bats - 11 or 13, I can't quite recall.
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Yeah, RmYN02 - the more complete of the two genomes. Definitely another genome in there
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It's another bat CoV closely related (but not identical) to others previously sequenced. Every yellow bar is an intrahost variant >10% (SNPs are all linked as far as I can tell, so I think it's just one additional genome) [shared file(s): Screen Shot 2020-09-18 at 16.19.28.png]