A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
-
Pretty interesting. Looking at RmYN02 the consensus is totally solid, however, I actually think there's another closely related bat CoV in there at a ~15% frequency. I'll dig a little deeper, but Tommy might be interested in looking at that
-
I SO hoped some of these intrahost mutations near the RBD or the FCS, but sadly no. Would have been cool!
-
You mean RmYN01? Yes, I've been asking Weifeng to get some analysis done on that for ages.
-
I think he said he only had an incomplete genome, including the RdRp, although even though that would be really interesting.
-
2020-09-18 16:11
Edward C. Holmes
Sorry, you mean in the RmYN02 reads? I seem to remember Weifeng discussing that before. Might even be noted in the paper. Can't remember. RmYN02 is pooled from a number of bats - 11 or 13, I can't quite recall.
-
Yeah, RmYN02 - the more complete of the two genomes. Definitely another genome in there
-
It's another bat CoV closely related (but not identical) to others previously sequenced. Every yellow bar is an intrahost variant >10% (SNPs are all linked as far as I can tell, so I think it's just one additional genome) [shared file(s): Screen Shot 2020-09-18 at 16.19.28.png]
-
Yes, I agree. I'll check back what we did - if anything - about this. It would be really interesting to see a phylogeny with that, RmYN02 and RmYN01 included.
-
I'm just going to pull that minority genome out - I'll keep you posted... Yeah, this is very interesting