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Slack / Private Message Drop, p.184 [SLACK_000398] · slack_pm:msg:01902

Page text: p.184 · original PDF

Date
2020-09-18 16:39
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker
Edward C. Holmes

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Great!

In context

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  1. 2020-09-18 16:18 Kristian G. Andersen open
    Yeah, RmYN02 - the more complete of the two genomes. Definitely another genome in there
  2. 2020-09-18 16:20 Kristian G. Andersen open
    It's another bat CoV closely related (but not identical) to others previously sequenced. Every yellow bar is an intrahost variant >10% (SNPs are all linked as far as I can tell, so I think it's just one additional genome) [shared file(s): Screen Shot 2020-09-18 at 16.19.28.png]
  3. 2020-09-18 16:25 Edward C. Holmes open
    Yes, I agree. I'll check back what we did - if anything - about this. It would be really interesting to see a phylogeny with that, RmYN02 and RmYN01 included.
  4. 2020-09-18 16:37 Kristian G. Andersen open
    I'm just going to pull that minority genome out - I'll keep you posted... Yeah, this is very interesting
  5. 2020-09-18 16:39 Edward C. Holmes
    Great!
  6. 2020-09-18 17:14 Kristian G. Andersen open
    Here's what I have assembled so far - all look great. Only need to assemble one of the remaining pangolin CoVs, which has a huge dataset. RBD in green. Conclusion? Nothing to see here.... as expected. [shared file(s): MP789.jpg, P1E.jpg, P2S.jpg, P2V.jpg, P3B.jpg,P4L.jpg, P5E.jpg, P5L.jpg, RaTG13.jpg, RmYN02.jpg]
  7. 2020-09-18 17:40 Edward C. Holmes open
    Great work! So annoying that these people are accusing of fabrication when they are honest scientists working hard. Makes by blood boil.
  8. 2020-09-18 18:03 Kristian G. Andersen open
    Here's the minor genome - probably not a complete genome, but definitely present. [shared file(s): minor_variant_genome.fa]
  9. 2020-09-18 18:03 Kristian G. Andersen open
    Alignment + tree [shared file(s): Alignment with minor RmYN02 RAxML Tree.nex, Alignment with minor RmYN02.nex]

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