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1. 2020-06-11 15:02 Robert F. Garry open
   "Then why would publish the sequence of a related bat virus that puts you in frame?" To throw off M15 and Pompeo?
2. 2020-06-11 15:13 Kristian G. Andersen open
   People have put furin sites into CoVs previously - here's one example from SARS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111780/
3. 2020-06-11 15:13 Kristian G. Andersen open
   There's a paper where they put it into a bat virus and shows it has much broader host range - I believe from Baric's group. I'll find it.
4. 2020-06-11 15:15 Edward C. Holmes open
   At S1/S2?
5. 2020-06-11 15:15 Kristian G. Andersen
   Yup - the paper above is _exactly_ where it was inserted in SARS2 - that's the part I missed previously (I have been aware of these papers all the time).
6. 2020-06-11 15:16 Kristian G. Andersen open
   (BUT, the inserted site _is not_ the same as in the paper - that would have been a dead giveaway)
7. 2020-06-11 15:16 Edward C. Holmes open
   We're going round in circles...that's the Follis paper...the first paper we discussed and I sent you in early Feb.
8. 2020-06-11 15:18 Edward C. Holmes open
   My take is that furin cleavage sites are *everywhere* in natural viruses e.g. MERS. I'm revising a paper on avianavulaviruses and they have one. To me, there is a strong natural prior.
9. 2020-06-11 15:18 Kristian G. Andersen open
   Yes - I have been aware of the Follis paper all along - I was _not_ aware that their insertion was exactly where it is inSARS2

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