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Slack / Private Message Drop, p.70 [SLACK_000284] · slack_pm:msg:00708

Page text: p.70 · original PDF

Date
2020-06-11 15:13
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen
Topics
Furin cleavage site and molecular features

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People have put furin sites into CoVs previously - here's one example from SARS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111780/

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People have put furin sites into CoVs previously - here's one example from SARS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111780/ own voice, substantive speaker_own asserts

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  1. 2020-06-11 14:34 Robert F. Garry open
    HKU1 actually does have an optimal furin site - some strains have a insert or deletion of SSS - yes some of these Shave predicted O-glycans [shared file(s): HKU-1 Spike.pdf]
  2. 2020-06-11 14:38 Robert F. Garry open
    "animal HKU1 comes from" Rodents maybe - probably
  3. 2020-06-11 14:44 Edward C. Holmes open
    May be. Perhaps rodents are involved in SARS-CoV-2? I'm really struggling to understand why someone would "put" a furin site into a random bat virus they had not previously sequenced and published. Has the Baric group ever done such an experiment? Accidental lab escape is one thing, but why would deliberately do this to a bat virus? Then why would publish the sequence of a related bat virus that puts you in frame? There was no need to that if you were guilty.
  4. 2020-06-11 15:02 Robert F. Garry open
    "Then why would publish the sequence of a related bat virus that puts you in frame?" To throw off M15 and Pompeo?
  5. 2020-06-11 15:13 Kristian G. Andersen
    People have put furin sites into CoVs previously - here's one example from SARS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111780/
  6. 2020-06-11 15:13 Kristian G. Andersen open
    There's a paper where they put it into a bat virus and shows it has much broader host range - I believe from Baric's group. I'll find it.
  7. 2020-06-11 15:15 Edward C. Holmes open
    At S1/S2?
  8. 2020-06-11 15:15 Kristian G. Andersen open
    Yup - the paper above is _exactly_ where it was inserted in SARS2 - that's the part I missed previously (I have been aware of these papers all the time).
  9. 2020-06-11 15:16 Kristian G. Andersen open
    (BUT, the inserted site _is not_ the same as in the paper - that would have been a dead giveaway)

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