Chat message

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

1. 2020-06-11 14:33 Edward C. Holmes open
   What about Bill Gallaher's evidence?
2. 2020-06-11 14:34 Robert F. Garry open
   HKU1 actually does have an optimal furin site - some strains have a insert or deletion of SSS - yes some of these Shave predicted O-glycans [shared file(s): HKU-1 Spike.pdf]
3. 2020-06-11 14:38 Robert F. Garry open
   "animal HKU1 comes from" Rodents maybe - probably
4. 2020-06-11 14:44 Edward C. Holmes open
   May be. Perhaps rodents are involved in SARS-CoV-2? I'm really struggling to understand why someone would "put" a furin site into a random bat virus they had not previously sequenced and published. Has the Baric group ever done such an experiment? Accidental lab escape is one thing, but why would deliberately do this to a bat virus? Then why would publish the sequence of a related bat virus that puts you in frame? There was no need to that if you were guilty.
5. 2020-06-11 15:02 Robert F. Garry
   "Then why would publish the sequence of a related bat virus that puts you in frame?" To throw off M15 and Pompeo?
6. 2020-06-11 15:13 Kristian G. Andersen open
   People have put furin sites into CoVs previously - here's one example from SARS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111780/
7. 2020-06-11 15:13 Kristian G. Andersen open
   There's a paper where they put it into a bat virus and shows it has much broader host range - I believe from Baric's group. I'll find it.
8. 2020-06-11 15:15 Edward C. Holmes open
   At S1/S2?
9. 2020-06-11 15:15 Kristian G. Andersen open
   Yup - the paper above is _exactly_ where it was inserted in SARS2 - that's the part I missed previously (I have been aware of these papers all the time).

Full conversation →