A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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May be. Perhaps rodents are involved in SARS-CoV-2? I'm really struggling to understand why someone would "put" a furin site into a random bat virus they had not previously sequenced and published. Has the Baric group ever done such an experiment? Accidental lab escape is one thing, but why would deliberately do this to a bat virus? Then why would publish the sequence of a related bat virus that puts you in frame? There was no need to that if you were guilty.
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"Then why would publish the sequence of a related bat virus that puts you in frame?" To throw off M15 and Pompeo?
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People have put furin sites into CoVs previously - here's one example from SARS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111780/
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There's a paper where they put it into a bat virus and shows it has much broader host range - I believe from Baric's group. I'll find it.
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2020-06-11 15:15
Edward C. Holmes
At S1/S2?
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Yup - the paper above is _exactly_ where it was inserted in SARS2 - that's the part I missed previously (I have been aware of these papers all the time).
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(BUT, the inserted site _is not_ the same as in the paper - that would have been a dead giveaway)
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We're going round in circles...that's the Follis paper...the first paper we discussed and I sent you in early Feb.
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My take is that furin cleavage sites are *everywhere* in natural viruses e.g. MERS. I'm revising a paper on avianavulaviruses and they have one. To me, there is a strong natural prior.