Slack / Private Message Drop — page 444

[Andrew Rambaut] Exactly [2021-01-23 17:21:15] [Kristian Andersen] That's weird. I mean, P.1. has many overlapping mutations so surely those at least must be right? [2021-01-23 17:21:34] [Andrew Rambaut] I thought they were more likely reversions than intermediates (still unlikely) but when I pointed them out to Tulio he said he thought they weren't real and they were fixing them. [2021-01-23 17:21:46] [Kristian Andersen] Oh. [2021-01-23 17:23:16] [Andrew Rambaut] I still think all three are chronic cases which have selected for antigenic escape within the host (and for B.1.1.7 at least increased transmissibility) and then these turned out to be in places where these were very fit. [2021-01-23 17:24:13] [Andrew Rambaut] Otherwise we would see these combinations coming up a lot. [2021-01-23 17:24:38] [Kristian Andersen] Yeah, that's true - either strong bottleneck (in single host) or very strong selection. [2021-01-23 17:24:38] [Andrew Rambaut] Not to say they couldn't given enough time but the chronic patient is just a kickstart [2021-01-23 17:25:32] [Kristian Andersen] Such an interesting virus evolutionarily speaking - I _do_ wonder what other shit it'll throw after us. [2021-01-23 17:26:49] [Eddie Holmes] Tulio and his tools. [2021-01-23 17:27:26] [Kristian Andersen] There was a reason we developed more robust tools... [2021-01-23 17:27:48] [Kristian Andersen] But as always - any one of these tools used in the wrong hands > disaster. [2021-01-23 17:31:05] [Andrew Rambaut] Yeah, he is using the ARTIC protocol on Illumina but then some crazy semi commercial software called Genome Detective [2021-01-23 17:32:14]