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Slack / Private Message Drop, p.444 [SLACK_000658] · slack_pm:msg:04597

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Tulio and his tools.

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A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-23 17:24 Andrew Rambaut open

Otherwise we would see these combinations coming up a lot.
2021-01-23 17:24 Kristian G. Andersen open

Yeah, that's true - either strong bottleneck (in single host) or very strong selection.
2021-01-23 17:24 Andrew Rambaut open

Not to say they couldn't given enough time but the chronic patient is just a kickstart
2021-01-23 17:25 Kristian G. Andersen open

Such an interesting virus evolutionarily speaking - I _do_ wonder what other shit it'll throw after us.
2021-01-23 17:26 Edward C. Holmes

Tulio and his tools.
2021-01-23 17:27 Kristian G. Andersen open

There was a reason we developed more robust tools...
2021-01-23 17:27 Kristian G. Andersen open

But as always - any one of these tools used in the wrong hands > disaster.
2021-01-23 17:31 Andrew Rambaut open

Yeah, he is using the ARTIC protocol on Illumina but then some crazy semi commercial software called Genome Detective
2021-01-23 17:32 Andrew Rambaut open

Which seems to be a web app with a 'premium' pay-for version. Tulio was involved in development which is probably why.