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Slack / Private Message Drop, p.444 [SLACK_000658] · slack_pm:msg:04591

Page text: p.444 · original PDF

Date
2021-01-23 17:21
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

Oh.

In context

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  1. 2021-01-23 17:20 Kristian G. Andersen open
    Eh?
  2. 2021-01-23 17:20 Andrew Rambaut open
    Exactly
  3. 2021-01-23 17:21 Kristian G. Andersen open
    That's weird. I mean, P.1. has many overlapping mutations so surely those at least must be right?
  4. 2021-01-23 17:21 Andrew Rambaut open
    I thought they were more likely reversions than intermediates (still unlikely) but when I pointed them out to Tulio hesaid he thought they weren't real and they were fixing them.
  5. 2021-01-23 17:21 Kristian G. Andersen
    Oh.
  6. 2021-01-23 17:23 Andrew Rambaut open
    I still think all three are chronic cases which have selected for antigenic escape within the host (and for B.1.1.7 atleast increased transmissibility) and then these turned out to be in places where these were very fit.
  7. 2021-01-23 17:24 Andrew Rambaut open
    Otherwise we would see these combinations coming up a lot.
  8. 2021-01-23 17:24 Kristian G. Andersen open
    Yeah, that's true - either strong bottleneck (in single host) or very strong selection.
  9. 2021-01-23 17:24 Andrew Rambaut open
    Not to say they couldn't given enough time but the chronic patient is just a kickstart

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