Slack / Private Message Drop — page 445

[Andrew Rambaut] Which seems to be a web app with a 'premium' pay-for version. Tulio was involved in development which is probably why. [2021-01-23 17:33:27] [Kristian Andersen] I remember I came across that - I think maybe even reviewing a paper with it. Really need to use iVar if he's on the Illumina platform. [2021-01-23 17:34:02] [Andrew Rambaut] I have mentioned it to him. [2021-01-23 17:49:05] [Andrew Rambaut] [thread - ID: 2021-01-23 17:49:05] Don't like this - L18F has cropped up quite a few times in B.1.1.7 but most of the 310 are in a single large cluster in one area of the country [2021-01-23 17:49:29] [Robert Garry] Andrew alluded to it and I agree it's true - some spots on the genome are "slippery" or prone to mutation. It's the variable and constant domain meme of HIV, fle etc. In one sense hopeful since it suggests that while the space for mutation/adaptation is large it's not infinite. As @Andrew Rambaut referenced a handful of immunosuppressed/cancer patients out there (two NEJM paper) with patients with overlapping or common mutation/deletions, a few of which actually flip back and forth in the "quasispecies.' The strongly immunosuppressed/persistent patients interesting - KGA aware of one of ours at Tulane that has stayed PCR positive for over 8 months. No provirus and a rudimentary proofing mechanism but still as Emma Hodcraft said a playground for the virus. [2021-01-23 17:49:59] [Andrew Rambaut] Got to go to bed and stop staring at mutations. [2021-01-23 17:54:23] [Robert Garry] Yes but I really don't want to think about the blissfully ignorant mess we'd be in if YOU hadn't been staring at mutations over the past several months. [2021-01-23 17:55:47] [Eddie Holmes] [thread - ID: 2021-01-23 17:55:47] Bob, you used the Q word. [2021-01-23 18:00:27] [Kristian Andersen] Oh oh. [2021-01-23 18:02:32] [Eddie Holmes] [thread - ID: 2021-01-23 18:02:32] Spent HOURS putting the GIPA together...kind of hoping that the 'grand wizard of EgoHealth' makes into the public domain [2021-01-23 18:02:45] [Kristian Andersen]