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Slack / Private Message Drop, pp.443-444 [SLACK_000657] · slack_pm:msg:04588

Page text: p.443, p.444 · original PDF

Date
2021-01-23 17:20
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut

Recipients on this medium are inferred from channel membership, not per-message addressing.

Exactly

In context

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  1. 2021-01-23 17:17 Andrew Rambaut open
    The plastic ones could have just been hitchhiking in the generating individual
  2. 2021-01-23 17:17 Kristian G. Andersen open
    True
  3. 2021-01-23 17:19 Andrew Rambaut open
    Trevor has been going around saying the RSA lineage arose in sequence based on some genomes with only some of the mutations but they are not old sequences and I have heard that Tulio uses some weird homebrew bioinformatics that may call for reference occasionally.
  4. 2021-01-23 17:20 Kristian G. Andersen open
    Eh?
  5. 2021-01-23 17:20 Andrew Rambaut
    Exactly
  6. 2021-01-23 17:21 Kristian G. Andersen open
    That's weird. I mean, P.1. has many overlapping mutations so surely those at least must be right?
  7. 2021-01-23 17:21 Andrew Rambaut open
    I thought they were more likely reversions than intermediates (still unlikely) but when I pointed them out to Tulio hesaid he thought they weren't real and they were fixing them.
  8. 2021-01-23 17:21 Kristian G. Andersen open
    Oh.
  9. 2021-01-23 17:23 Andrew Rambaut open
    I still think all three are chronic cases which have selected for antigenic escape within the host (and for B.1.1.7 atleast increased transmissibility) and then these turned out to be in places where these were very fit.

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