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Slack / Private Message Drop, p.380 [SLACK_000594] · slack_pm:msg:03959

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What does nsp6 do again? Is it possible it's directly interacting with the spike protein to determine e.g., binding?

Extracted statements

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Statement	Grade	Attribution	Stance
Is it possible it's directly interacting with the spike protein to determine e.g., binding?	needs context	speaker_own	questions

Statement

Grade

Attribution

Stance

Is it possible it's directly interacting with the spike protein to determine e.g., binding?

needs context

speaker_own

questions

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-11 14:41 Andrew Rambaut open

The Japanese/Manaus cluster has the same nsp6 deletion that the UK and South African lineages have
2021-01-11 14:43 Edward C. Holmes open

Wowser. That's not chance.
2021-01-11 14:51 Robert F. Garry open

Places where the polymerase has tendency to slip and skip?
2021-01-11 15:05 Andrew Rambaut open

The Manaus/Japanese cluster has a very long branch (too long) - possibly another 'chronic infection' event?
2021-01-11 15:06 Kristian G. Andersen

What does nsp6 do again? Is it possible it's directly interacting with the spike protein to determine e.g., binding?
2021-01-11 15:06 Andrew Rambaut open

```ORF1ab synT733C F681L I760T synC2749T S1188L K1795Q del11288-11296 (3675-3677 SGF) synC12778T synC13860T E5662D spike L18F T20N P26S D138Y R190S K417T E484K N501Y H655Y T1027I ORF3a: C174G ORF8: E92K N: P80R synA28881T synG28882C```
2021-01-11 15:06 Kristian G. Andersen open

Bloody hell
2021-01-11 15:07 Edward C. Holmes open

WTF.
2021-01-11 15:08 Andrew Rambaut open

Just bonkers