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Slack / Private Message Drop, pp.1030-1031 [SLACK_001244] · slack_pm:msg:10773

Page text: p.1030, p.1031 · original PDF

Date: 2021-11-26 09:08
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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Oh yeah!

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-11-26 09:06 Andrew Rambaut open

We are currently looking for the closest potentially basal genome in humans but at the moment it definitely looks like being 2020. I am struggling to see how a that could be a chronic infection followed by transmission. I doubt an HIV patient would survive that long with a CoV infection doing all this shit.
2021-11-26 09:07 Andrew Rambaut open

A non-human host would also explain adaptation in the RBD to a different ACE-2? It may have antigenic consequences in humans but that is coincidental because it is the RBD
2021-11-26 09:07 Robert F. Garry open

CHeck out the figure in the other channel - 7-of 7 mutations seen in rodents are in Nu - that's unlikely....
2021-11-26 09:08 Andrew Rambaut open

We are working with Tulio on this so I would prefer not to broaden it out too much.
2021-11-26 09:08 Robert F. Garry

Oh yeah!
2021-11-26 09:09 Andrew Rambaut open

I got excited because the 679K mutation is also seen in C.1.2 (i.e., in South Africa) _but_ it is a different codon in Nuand doesn't have 681H so probably convergent
2021-11-26 09:09 Andrew Rambaut open

Back in the old Beta days we were discussing this critter:https://en.wikipedia.org/wiki/Genet_(animal)
2021-11-26 09:10 Andrew Rambaut open

Apparently is often commensal with humans (living in roofs etc).
2021-11-26 09:11 Andrew Rambaut open

I know that Civets are not a favoured host but again, perhaps that would explain the RBD - i.e. mustelids are closerto humans, civets require more adaptation.

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