Chat message

Slack / Private Message Drop, p.1030 [SLACK_001244] · slack_pm:msg:10770

Date: 2021-11-26 09:07
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut
Topics: Furin cleavage site and molecular features

Recipients on this medium are inferred from channel membership, not per-message addressing.

A non-human host would also explain adaptation in the RBD to a different ACE-2? It may have antigenic consequences in humans but that is coincidental because it is the RBD

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
A non-human host would also explain adaptation in the RBD to a different ACE-2?	needs context	speaker_own	questions
It may have antigenic consequences in humans but that is coincidental because it is the RBD	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

A non-human host would also explain adaptation in the RBD to a different ACE-2?

needs context

speaker_own

questions

It may have antigenic consequences in humans but that is coincidental because it is the RBD

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-11-26 09:04 Andrew Rambaut open

OK. Peeps. We are definitely considering the human->animal->human origins of Nu (as it may or may not be called).
2021-11-26 09:04 Andrew Rambaut open

Would be happy to work with you all on this.
2021-11-26 09:06 Andrew Rambaut open

We are currently looking for the closest potentially basal genome in humans but at the moment it definitely looks like being 2020. I am struggling to see how a that could be a chronic infection followed by transmission. I doubt an HIV patient would survive that long with a CoV infection doing all this shit.
2021-11-26 09:07 Andrew Rambaut

A non-human host would also explain adaptation in the RBD to a different ACE-2? It may have antigenic consequences in humans but that is coincidental because it is the RBD
2021-11-26 09:07 Robert F. Garry open

CHeck out the figure in the other channel - 7-of 7 mutations seen in rodents are in Nu - that's unlikely....
2021-11-26 09:08 Andrew Rambaut open

We are working with Tulio on this so I would prefer not to broaden it out too much.
2021-11-26 09:08 Robert F. Garry open

Oh yeah!
2021-11-26 09:09 Andrew Rambaut open

I got excited because the 679K mutation is also seen in C.1.2 (i.e., in South Africa) _but_ it is a different codon in Nuand doesn't have 681H so probably convergent

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