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Slack / Private Message Drop, p.1031 [SLACK_001245] · slack_pm:msg:10777

Page text: p.1031 · original PDF

Date
2021-11-26 09:11
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut
Topics
Furin cleavage site and molecular features

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I know that Civets are not a favoured host but again, perhaps that would explain the RBD - i.e. mustelids are closerto humans, civets require more adaptation.

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I know that Civets are not a favoured host but again, perhaps that would explain the RBD - i.e. mustelids are closerto humans, civets require more adaptation. needs context uncertain explicit hedge asserts

In context

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  1. 2021-11-26 09:08 Robert F. Garry open
    Oh yeah!
  2. 2021-11-26 09:09 Andrew Rambaut open
    I got excited because the 679K mutation is also seen in C.1.2 (i.e., in South Africa) _but_ it is a different codon in Nuand doesn't have 681H so probably convergent
  3. 2021-11-26 09:09 Andrew Rambaut open
    Back in the old Beta days we were discussing this critter:https://en.wikipedia.org/wiki/Genet_(animal)
  4. 2021-11-26 09:10 Andrew Rambaut open
    Apparently is often commensal with humans (living in roofs etc).
  5. 2021-11-26 09:11 Andrew Rambaut
    I know that Civets are not a favoured host but again, perhaps that would explain the RBD - i.e. mustelids are closerto humans, civets require more adaptation.
  6. 2021-11-26 09:11 Andrew Rambaut open
    Rodents would also be likely, obviously.
  7. 2021-11-26 09:13 Robert F. Garry open
    Nu does have Y505H previously seen in a lion...plus a few other catty ones.
  8. 2021-11-26 09:14 Robert F. Garry open
    Genets are cat-like right?
  9. 2021-11-26 09:17 Andrew Rambaut open
    Yes!

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