Chat message

Slack / Private Message Drop, p.1031 [SLACK_001245] · slack_pm:msg:10774

Date: 2021-11-26 09:09
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

Recipients on this medium are inferred from channel membership, not per-message addressing.

I got excited because the 679K mutation is also seen in C.1.2 (i.e., in South Africa) _but_ it is a different codon in Nuand doesn't have 681H so probably convergent

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-11-26 09:07 Andrew Rambaut open

A non-human host would also explain adaptation in the RBD to a different ACE-2? It may have antigenic consequences in humans but that is coincidental because it is the RBD
2021-11-26 09:07 Robert F. Garry open

CHeck out the figure in the other channel - 7-of 7 mutations seen in rodents are in Nu - that's unlikely....
2021-11-26 09:08 Andrew Rambaut open

We are working with Tulio on this so I would prefer not to broaden it out too much.
2021-11-26 09:08 Robert F. Garry open

Oh yeah!
2021-11-26 09:09 Andrew Rambaut

I got excited because the 679K mutation is also seen in C.1.2 (i.e., in South Africa) _but_ it is a different codon in Nuand doesn't have 681H so probably convergent
2021-11-26 09:09 Andrew Rambaut open

Back in the old Beta days we were discussing this critter:https://en.wikipedia.org/wiki/Genet_(animal)
2021-11-26 09:10 Andrew Rambaut open

Apparently is often commensal with humans (living in roofs etc).
2021-11-26 09:11 Andrew Rambaut open

I know that Civets are not a favoured host but again, perhaps that would explain the RBD - i.e. mustelids are closerto humans, civets require more adaptation.
2021-11-26 09:11 Andrew Rambaut open

Rodents would also be likely, obviously.

Full conversation →