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Slack / Private Message Drop, pp.644-645 [SLACK_000858] · slack_pm:msg:06753

Page text: p.644, p.645 · original PDF

Date
2021-03-27 10:19
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut

Recipients on this medium are inferred from channel membership, not per-message addressing.

The Malaysian one you included has an additional SNP difference away from RaTG13 - I am pretty sure there was one that was identical to WA1 (but I did this analysis back in July so have lost all memory of it. Will dig out my notes.

In context

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  1. 2021-03-27 09:34 Andrew Rambaut open
    Interestingly also there is a Malaysian case with exactly the same WA1 haplotype (Malaysia... pangolins...). But probably coincidence.
  2. 2021-03-27 09:45 Kristian G. Andersen open
    Yup! Take a look at the alignment I shared yesterday... I think it's interesting
  3. 2021-03-27 10:08 Robert F. Garry open
    Do we know anymore details about the Malaysian and WA1 cases - seems key.
  4. 2021-03-27 10:08 Robert F. Garry open
    Do we know anything more about the epi of the Malaysian or WA1 cases - seems very key. [shared file(s): image.png]
  5. 2021-03-27 10:19 Andrew Rambaut
    The Malaysian one you included has an additional SNP difference away from RaTG13 - I am pretty sure there was one that was identical to WA1 (but I did this analysis back in July so have lost all memory of it. Will dig out my notes.
  6. 2021-03-27 10:21 Robert F. Garry open
    https://www.seattletimes.com/seattle-news/health/case-of-wuhan-coronavirus-detected-in-washington-state-first-inunited-states/ Here's the news article about WA1
  7. 2021-03-27 10:34 Robert F. Garry open
    It's 416886 from February 4, 2020 according to @Andrew Rambaut Dec 6.
  8. 2021-03-27 10:35 Andrew Rambaut open
    I don't know what to make of the Angolan/Tanzanian ones - need to get into a different head space for that.
  9. 2021-03-27 10:54 Robert F. Garry open
    I'm convinced based on serology that "something" with sarbecoviruses has been going on in Africa for a while. The rest of you have some appropriate "head space" to consider this. I have *no clue* myself, but what are the odds of aseparate emergence of a deeper lineage A ancestor? Seems impossible to consider, but we live in a strange world. Are any other mutations in immunosuppressed patients "back to bat?"

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