Slack / Private Message Drop — page 644

Totally agree on the importance of pointing out why they decontaminated the market - I have been saying the same since January 2020. Imagine if they hadn't done that... It's just idiotic to say that they did this "to cover up". As for links to other markets in the beginning - @Robert Garry do you have any good articles on that? I'd like to dig a little deeper into the A/B split taking that into consideration... [2021-03-27 08:49:26] [Robert Garry] Qun2020:- Worth revisiting in light of new info about lineages A and B. actually has the information that the lab leak group want to dismiss- the early cases were associated with other wet markets not just the Huanan Wet Market. [shared file(s): nejmoa2001316.pdf] [2021-03-27 08:55:03] [Robert Garry] Here is the key Table about the early cases - All the Huanan Market cases lineage B. The other early ones linked to other wet markets lineage A. @Andrew Rambaut or @Eddie Holmes may have more detailed info. I tried to capture this in my natural origins diagram above. [shared file(s): image.png] [2021-03-27 08:58:46] [Robert Garry] Of course A "ancestral" to B so any theory on early emergence has to capture the fact that both lineages associated with wet markets early on.... [2021-03-27 09:02:34] [Robert Garry] Other key fact - just to put it here- WA1 - a traveler from Wuhan to Washington State - lineage A had 3 ancestra snps per @Andrew Rambaut [2021-03-27 09:07:56] [Kristian Andersen] Thanks Bob. I'll head to the desert for a few hours to clear my mind, but I'll comb through this carefully. And yes, agreed about WA1 and I actually speculated about that a while back - https://twitter.com/K_G_Andersen/status/1338993282148302848?s=20 [2021-03-27 09:34:00] [Andrew Rambaut] Interestingly also there is a Malaysian case with exactly the same WA1 haplotype (Malaysia... pangolins...). But probably coincidence. [2021-03-27 09:45:25] [Kristian Andersen] Yup! Take a look at the alignment I shared yesterday... I think it's interesting [2021-03-27 10:08:38] [Robert Garry] Do we know anymore details about the Malaysian and WA1 cases - seems key. [2021-03-27 10:08:38] [Robert Garry] Do we know anything more about the epi of the Malaysian or WA1 cases - seems very key. [shared file(s): image.png] [2021-03-27 10:19:42] [Andrew Rambaut]