Chat message

Slack / Private Message Drop, p.644 [SLACK_000858] · slack_pm:msg:06749

Date: 2021-03-27 09:34
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut
Topics: Natural origin / zoonotic spillover

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Interestingly also there is a Malaysian case with exactly the same WA1 haplotype (Malaysia... pangolins...). But probably coincidence.

Extracted statements

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Statement	Grade	Attribution	Stance
Interestingly also there is a Malaysian case with exactly the same WA1 haplotype (Malaysia... pangolins...).	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

Interestingly also there is a Malaysian case with exactly the same WA1 haplotype (Malaysia... pangolins...).

own voice, substantive

speaker_own

asserts

In context

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2021-03-27 08:55 Robert F. Garry open

Here is the key Table about the early cases - All the Huanan Market cases lineage B. The other early ones linked toother wet markets lineage A. @Andrew Rambaut or @Eddie Holmes may have more detailed info. I tried to capture this in my natural origins diagram above. [shared file(s): image.png]
2021-03-27 08:58 Robert F. Garry open

Of course A "ancestral" to B so any theory on early emergence has to capture the fact that both lineages associated with wet markets early on....
2021-03-27 09:02 Robert F. Garry open

Other key fact - just to put it here- WA1 - a traveler from Wuhan to Washington State - lineage A had 3 ancestrasnps per @Andrew Rambaut
2021-03-27 09:07 Kristian G. Andersen open

Thanks Bob. I'll head to the desert for a few hours to clear my mind, but I'll comb through this carefully. And yes, agreed about WA1 and I actually speculated about that a while back -https://twitter.com/K_G_Andersen/status/1338993282148302848?s=20
2021-03-27 09:34 Andrew Rambaut

Interestingly also there is a Malaysian case with exactly the same WA1 haplotype (Malaysia... pangolins...). But probably coincidence.
2021-03-27 09:45 Kristian G. Andersen open

Yup! Take a look at the alignment I shared yesterday... I think it's interesting
2021-03-27 10:08 Robert F. Garry open

Do we know anymore details about the Malaysian and WA1 cases - seems key.
2021-03-27 10:08 Robert F. Garry open

Do we know anything more about the epi of the Malaysian or WA1 cases - seems very key. [shared file(s): image.png]
2021-03-27 10:19 Andrew Rambaut open

The Malaysian one you included has an additional SNP difference away from RaTG13 - I am pretty sure there was one that was identical to WA1 (but I did this analysis back in July so have lost all memory of it. Will dig out my notes.

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