Chat message

Slack / Private Message Drop, p.576 [SLACK_000790] · slack_pm:msg:06018

Date: 2021-03-08 15:06
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut
Topics: Wuhan Institute of Virology collaboration

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But that means these ideas about WIV sampling viruses from the wild and one of the accidentally escapes might bewrong?

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Statement	Grade	Attribution	Stance
But that means these ideas about WIV sampling viruses from the wild and one of the accidentally escapes might bewrong?	needs context	uncertain explicit hedge	questions

Statement

Grade

Attribution

Stance

But that means these ideas about WIV sampling viruses from the wild and one of the accidentally escapes might bewrong?

needs context

uncertain explicit hedge

questions

In context

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2021-03-08 14:58 Edward C. Holmes open

We and colleagues do this all the time. The plan is always to get into a cold chain as quick as possible for sequencing. We do have a portable -80C we use in some cases, but it's usually a case of storage in RNAlater.
2021-03-08 15:02 Robert F. Garry open

In general the RNA (even fragmented non-infectious) hangs a lot longer than any infectious virus.
2021-03-08 15:04 Kristian G. Andersen open

Yeah, culturing viruses from bats or any other animal = bloody hard. I wouldn't be surprised that if you had 50 bats all infected with SC2, you'd only be able to grow it out of one of those.
2021-03-08 15:04 Robert F. Garry open

Explains some of the problems in the diagnostic space - Start mixing in detection with antigen assays [which correlates not so well with infectious virus or RNA] and it gets complicated fast.
2021-03-08 15:06 Andrew Rambaut

But that means these ideas about WIV sampling viruses from the wild and one of the accidentally escapes might bewrong?
2021-03-08 15:07 Kristian G. Andersen open

I think most of those people underestimate how incredibly hard it is to grow stuff from such samples, yes.
2021-03-08 15:07 Robert F. Garry open

Screening species with serology though I think is the way to go - that is why Lin-Fa's ACE2BOB makes sense - find the species that have antibodies then trap the hell out of them until you get lucky and hit one at peak viremia/RNA.
2021-03-08 15:07 Kristian G. Andersen open

I think they assume - 10,000 samples = 10,000 chances for SC2 to hop out of a tube. Nope.
2021-03-08 15:08 Robert F. Garry open

@Andrew Rambaut Hammer hits nail!

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