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Slack / Private Message Drop, p.417 [SLACK_000631] · slack_pm:msg:04310

Page text: p.417 · original PDF

Date: 2021-01-18 10:55
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

Recipients on this medium are inferred from channel membership, not per-message addressing.

Doug, Nelly, Eek and N417T fit - binds to ace2 like hell - and very immune evasive.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-18 10:30 Kristian G. Andersen open

I like this Salim guy though - very very good.
2021-01-18 10:39 Kristian G. Andersen open

Salim Abdool Karim - holy smokes, such a good scientific communicator. Probably the best I have seen during the entire pandemic - I feel like an idiot I didn't know about him before watching this presentation. https://en.wikipedia.org/wiki/Salim_Abdool_Karim
2021-01-18 10:42 Robert F. Garry open

Yes good - I chaired the study section that reviewed the last round of AIDS clinical trials groups grants a few months back. Karim and his wife clearly had the best application of the bunch. Not close.
2021-01-18 10:50 Kristian G. Andersen open

I'm impressed.
2021-01-18 10:55 Robert F. Garry

Doug, Nelly, Eek and N417T fit - binds to ace2 like hell - and very immune evasive.
2021-01-18 11:00 Kristian G. Andersen open

Exactly - Nelly and her bad friends. "In about 50% of cases there was no recognition of the new virus by preexisting antibodies". Some of the most chilling words of the pandemic. Let's not fool ourselves that T cells will come and save the day - this is fucking serious (and is what a good proportion of us have been warning about for months -many months before even seeing these new variants). This is one sly fucker.
2021-01-18 11:10 Robert F. Garry open

No way to sugar coat it. My expectations are lowered a lot.
2021-01-18 11:13 Kristian G. Andersen open

I was unfortunately already there - I hate the fact that my most pessimistic viewpoints tend to be confirmed by this virus over and over again.
2021-01-18 11:24 Robert F. Garry open

I updated the Christmas Card figure on virological to include P.1. I'm also "done" messing with the new post/figure -Karthik offered no changes [but generated some interesting data on indels that'll be useful later on] and Bill Gallaher suggested several additions which I cut down - incorporating a few. Please let me know if there are any edits that are needed. This whole VoC situation is a rapidly changing mess. Probably be a dozen extra facts that should have been added in a few hours...

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