Slack / Private Message Drop — page 417

[2021-01-18 10:50:24] [Kristian Andersen] I'm impressed. [2021-01-18 10:55:26] [Robert Garry] Doug, Nelly, Eek and N417T fit - binds to ace2 like hell - and very immune evasive. [2021-01-18 11:00:14] [Kristian Andersen] Exactly - Nelly and her bad friends. "In about 50% of cases there was no recognition of the new virus by preexisting antibodies". Some of the most chilling words of the pandemic. Let's not fool ourselves that T cells will come and save the day - this is fucking serious (and is what a good proportion of us have been warning about for months - many months before even seeing these new variants). This is one sly fucker. [2021-01-18 11:10:01] [Robert Garry] No way to sugar coat it. My expectations are lowered a lot. [2021-01-18 11:13:34] [Kristian Andersen] I was unfortunately already there - I hate the fact that my most pessimistic viewpoints tend to be confirmed by this virus over and over again. [2021-01-18 11:24:03] [Robert Garry] I updated the Christmas Card figure on virological to include P.1. I'm also "done" messing with the new post/figure - Karthik offered no changes [but generated some interesting data on indels that'll be useful later on] and Bill Gallaher suggested several additions which I cut down - incorporating a few. Please let me know if there are any edits that are needed. This whole VoC situation is a rapidly changing mess. Probably be a dozen extra facts that should have been added in a few hours... [2021-01-18 11:28:16] [Kristian Andersen] I'll take a look now. [2021-01-18 11:49:16] [Eddie Holmes] Fuck [2021-01-18 12:05:21] [Kristian Andersen] That's basically the perfect summary. [2021-01-18 12:07:17] [Kristian Andersen] If we all dig deep and for a moment forget that we are humans that like other people live in part denial, are we truly surprised by these results? It's a general question, because I have observed this in myself since the very beginning of the pandemic - e.g., in the beginning of it communicating that "maybe it isn't going to be so bad" because at the end of the day that's really what I wanted, but deep down my training was telling me I was a wishful idiot. [2021-01-18 12:11:22] [Eddie Holmes] Not surprised it has happened, but surprised it has happened so quickly. [2021-01-18 12:12:08]