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1. 2021-01-18 10:50 Kristian G. Andersen open
   I'm impressed.
2. 2021-01-18 10:55 Robert F. Garry open
   Doug, Nelly, Eek and N417T fit - binds to ace2 like hell - and very immune evasive.
3. 2021-01-18 11:00 Kristian G. Andersen open
   Exactly - Nelly and her bad friends. "In about 50% of cases there was no recognition of the new virus by preexisting antibodies". Some of the most chilling words of the pandemic. Let's not fool ourselves that T cells will come and save the day - this is fucking serious (and is what a good proportion of us have been warning about for months -many months before even seeing these new variants). This is one sly fucker.
4. 2021-01-18 11:10 Robert F. Garry open
   No way to sugar coat it. My expectations are lowered a lot.
5. 2021-01-18 11:13 Kristian G. Andersen
   I was unfortunately already there - I hate the fact that my most pessimistic viewpoints tend to be confirmed by this virus over and over again.
6. 2021-01-18 11:24 Robert F. Garry open
   I updated the Christmas Card figure on virological to include P.1. I'm also "done" messing with the new post/figure -Karthik offered no changes [but generated some interesting data on indels that'll be useful later on] and Bill Gallaher suggested several additions which I cut down - incorporating a few. Please let me know if there are any edits that are needed. This whole VoC situation is a rapidly changing mess. Probably be a dozen extra facts that should have been added in a few hours...
7. 2021-01-18 11:28 Kristian G. Andersen open
   I'll take a look now.
8. 2021-01-18 11:49 Edward C. Holmes open
   Fuck
9. 2021-01-18 12:05 Kristian G. Andersen open
   That's basically the perfect summary.

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