Chat message

Slack / Private Message Drop, p.417 [SLACK_000631] · slack_pm:msg:04314

Date: 2021-01-18 11:24
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

Recipients on this medium are inferred from channel membership, not per-message addressing.

I updated the Christmas Card figure on virological to include P.1. I'm also "done" messing with the new post/figure -Karthik offered no changes [but generated some interesting data on indels that'll be useful later on] and Bill Gallaher suggested several additions which I cut down - incorporating a few. Please let me know if there are any edits that are needed. This whole VoC situation is a rapidly changing mess. Probably be a dozen extra facts that should have been added in a few hours...

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-18 10:55 Robert F. Garry open

Doug, Nelly, Eek and N417T fit - binds to ace2 like hell - and very immune evasive.
2021-01-18 11:00 Kristian G. Andersen open

Exactly - Nelly and her bad friends. "In about 50% of cases there was no recognition of the new virus by preexisting antibodies". Some of the most chilling words of the pandemic. Let's not fool ourselves that T cells will come and save the day - this is fucking serious (and is what a good proportion of us have been warning about for months -many months before even seeing these new variants). This is one sly fucker.
2021-01-18 11:10 Robert F. Garry open

No way to sugar coat it. My expectations are lowered a lot.
2021-01-18 11:13 Kristian G. Andersen open

I was unfortunately already there - I hate the fact that my most pessimistic viewpoints tend to be confirmed by this virus over and over again.
2021-01-18 11:24 Robert F. Garry

I updated the Christmas Card figure on virological to include P.1. I'm also "done" messing with the new post/figure -Karthik offered no changes [but generated some interesting data on indels that'll be useful later on] and Bill Gallaher suggested several additions which I cut down - incorporating a few. Please let me know if there are any edits that are needed. This whole VoC situation is a rapidly changing mess. Probably be a dozen extra facts that should have been added in a few hours...
2021-01-18 11:28 Kristian G. Andersen open

I'll take a look now.
2021-01-18 11:49 Edward C. Holmes open

Fuck
2021-01-18 12:05 Kristian G. Andersen open

That's basically the perfect summary.
2021-01-18 12:07 Kristian G. Andersen open

If we all dig deep and for a moment forget that we are humans that like other people live in part denial, are we truly surprised by these results? It's a general question, because I have observed this in myself since the very beginningof the pandemic - e.g., in the beginning of it communicating that "maybe it isn't going to be so bad" because at the end of the day that's really what I wanted, but deep down my training was telling me I was a wishful idiot.

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