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Slack / Private Message Drop, p.416 [SLACK_000630] · slack_pm:msg:04306

Page text: p.416 · original PDF

Date
2021-01-18 10:30
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

I like this Salim guy though - very very good.

In context

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  1. 2021-01-18 10:14 Kristian G. Andersen open
    https://twitter.com/AdamJKucharski/status/1351228542143651840?s=20
  2. 2021-01-18 10:16 Kristian G. Andersen open
    Starts ~40 mins: https://www.youtube.com/watch?v=Ja_tLG8CLAc
  3. 2021-01-18 10:17 Robert F. Garry open
    That's worse than expected. Much worse.
  4. 2021-01-18 10:26 Kristian G. Andersen open
    It's bad indeed - very bad. To me it's not unexpected though - the RSA lineage has multiple mutations that had already been shown to affect immunity, so I can't say I'm surprised (this is unlike b117 - that one has less mutations that seem related to escape). It's much worse than I could have _hoped_ for though. Add to this that I'm getting increasingly concerned that this is because Eek leads to general immune escape and isn't just linked to changing asimple B cell epitope.
  5. 2021-01-18 10:30 Kristian G. Andersen
    I like this Salim guy though - very very good.
  6. 2021-01-18 10:39 Kristian G. Andersen open
    Salim Abdool Karim - holy smokes, such a good scientific communicator. Probably the best I have seen during the entire pandemic - I feel like an idiot I didn't know about him before watching this presentation. https://en.wikipedia.org/wiki/Salim_Abdool_Karim
  7. 2021-01-18 10:42 Robert F. Garry open
    Yes good - I chaired the study section that reviewed the last round of AIDS clinical trials groups grants a few months back. Karim and his wife clearly had the best application of the bunch. Not close.
  8. 2021-01-18 10:50 Kristian G. Andersen open
    I'm impressed.
  9. 2021-01-18 10:55 Robert F. Garry open
    Doug, Nelly, Eek and N417T fit - binds to ace2 like hell - and very immune evasive.

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