Chat message

Slack / Private Message Drop, p.312 [SLACK_000526] · slack_pm:msg:03274

Date: 2020-12-14 10:13
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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It's a little weird in that respect - the patient above essentially has no - or very limited - humoral immunity, but thesignatures still look like immune escape - or maybe something else is going on. So yes, even immunecompromisedpatients can shed viruses that may have signatures of immune escape.

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2020-12-14 10:07 Andrew Rambaut open

@Robert Garry Why do you say that?
2020-12-14 10:09 Andrew Rambaut open

Any thought if it would likely be an immunecompromised patient - could a weak immune response enhance selection for escape? Or do we know of any asymptomatic shedders - which would allow for the transmission if the person was out and about?
2020-12-14 10:10 Robert F. Garry open

@Robert Garry It's the insertion P in PRRA
2020-12-14 10:11 Robert F. Garry open

@Robert Garry Would be surprising if it didn't affect cleavage...
2020-12-14 10:13 Kristian G. Andersen

It's a little weird in that respect - the patient above essentially has no - or very limited - humoral immunity, but thesignatures still look like immune escape - or maybe something else is going on. So yes, even immunecompromisedpatients can shed viruses that may have signatures of immune escape.
2020-12-14 10:14 Andrew Rambaut open

@Robert Garry Ooh. Missed that.
2020-12-14 10:16 Robert F. Garry open

@Robert Garry That's the one I'd be concerned about.
2020-12-14 10:17 Kristian G. Andersen open

@Robert Garry Oh, interesting. It's rare - but parallel evolution? [shared file(s): Screen Shot 2020-12-14 at 10.16.54.png]
2020-12-14 10:18 Kristian G. Andersen open

@Robert Garry P > H still have FCS, but affects glycans and likely regulation?

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