A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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Yeah, the spike mutations would suggest chronic - but a lot of mutations outside spike too, which is a little peculiar tome.
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Chronic shedding with immune selection definitely a possibility. N501 is next to a short disordered region in S structures - a clear signal that it's an epitope.
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P681H is also VERY interesting....how common is this?
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There is an ORF8 stop at amino acid 27 and then a number appear after that suggesting it has become non functional.
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2020-12-14 10:07
Andrew Rambaut
@Robert Garry Why do you say that?
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Any thought if it would likely be an immunecompromised patient - could a weak immune response enhance selection for escape? Or do we know of any asymptomatic shedders - which would allow for the transmission if the person was out and about?
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@Robert Garry It's the insertion P in PRRA
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@Robert Garry Would be surprising if it didn't affect cleavage...
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It's a little weird in that respect - the patient above essentially has no - or very limited - humoral immunity, but thesignatures still look like immune escape - or maybe something else is going on. So yes, even immunecompromisedpatients can shed viruses that may have signatures of immune escape.