Chat message

Slack / Private Message Drop, p.312 [SLACK_000526] · slack_pm:msg:03278

Recipients on this medium are inferred from channel membership, not per-message addressing.

@Robert Garry P > H still have FCS, but affects glycans and likely regulation?

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-14 10:13 Kristian G. Andersen open

It's a little weird in that respect - the patient above essentially has no - or very limited - humoral immunity, but thesignatures still look like immune escape - or maybe something else is going on. So yes, even immunecompromisedpatients can shed viruses that may have signatures of immune escape.
2020-12-14 10:14 Andrew Rambaut open

@Robert Garry Ooh. Missed that.
2020-12-14 10:16 Robert F. Garry open

@Robert Garry That's the one I'd be concerned about.
2020-12-14 10:17 Kristian G. Andersen open

@Robert Garry Oh, interesting. It's rare - but parallel evolution? [shared file(s): Screen Shot 2020-12-14 at 10.16.54.png]
2020-12-14 10:18 Kristian G. Andersen

@Robert Garry P > H still have FCS, but affects glycans and likely regulation?
2020-12-14 10:18 Andrew Rambaut open

Can you send a link to that nextstrain view?
2020-12-14 10:18 Robert F. Garry open

@Robert Garry Yeah both of those...
2020-12-14 10:20 Kristian G. Andersen open

https://nextstrain.org/ncov/global?c=gt-S_681
2020-12-14 10:29 Robert F. Garry open

"Or do we know of any asymptomatic shedders - which would allow for the transmission if the person was out and about?" This is the question we're going to answer one way or the other if the vaccines are not that good at sterilizing immunity (hopefully most are).