Slack / Private Message Drop — page 312

[2020-12-14 10:07:00] [Andrew Rambaut] [thread - ID: 2020-12-14 09:56:19] @Robert Garry Why do you say that? [2020-12-14 10:09:03] [Andrew Rambaut] Any thought if it would likely be an immunecompromised patient - could a weak immune response enhance selection for escape? Or do we know of any asymptomatic shedders - which would allow for the transmission if the person was out and about? [2020-12-14 10:10:56] [Robert Garry] [thread - ID: 2020-12-14 09:56:19] @Robert Garry It's the insertion P in PRRA [2020-12-14 10:11:23] [Robert Garry] [thread - ID: 2020-12-14 09:56:19] @Robert Garry Would be surprising if it didn't affect cleavage... [2020-12-14 10:13:26] [Kristian Andersen] It's a little weird in that respect - the patient above essentially has no - or very limited - humoral immunity, but the signatures still look like immune escape - or maybe something else is going on. So yes, even immunecompromised patients can shed viruses that may have signatures of immune escape. [2020-12-14 10:14:59] [Andrew Rambaut] [thread - ID: 2020-12-14 09:56:19] @Robert Garry Ooh. Missed that. [2020-12-14 10:16:19] [Robert Garry] [thread - ID: 2020-12-14 09:56:19] @Robert Garry That's the one I'd be concerned about. [2020-12-14 10:17:36] [Kristian Andersen] [thread - ID: 2020-12-14 09:56:19] @Robert Garry Oh, interesting. It's rare - but parallel evolution? [shared file(s): Screen Shot 2020-12-14 at 10.16.54.png] [2020-12-14 10:18:08] [Kristian Andersen] [thread - ID: 2020-12-14 09:56:19] @Robert Garry P > H still have FCS, but affects glycans and likely regulation? [2020-12-14 10:18:25] [Andrew Rambaut] Can you send a link to that nextstrain view? [2020-12-14 10:18:31] [Robert Garry]