Slack / Private Message Drop — page 947

[2021-06-19 13:30:54] [Robert Garry] @Kristian Andersen let me know if you want to have call later today/tomorrow before Tony/FrancisII - interested in your thoughts [2021-06-19 14:08:45] [Kristian Andersen] Yeah cutting my trip short for this and will be back tonight. Can we set up a call Sunday am with Andrew too? [2021-06-19 14:09:41] [Kristian Andersen] I haven't looked at any of this yet [2021-06-19 14:44:49] [Robert Garry] "The second explanation, which was proposed in a blog post by Garry (2021) and amplified by a popular podcast (Racaniello _et al._ 2021), is that there were multiple zoonoses from distinct markets, with the Huanan Seafood Market being the source of viruses in clade B, and some other market being the source of viruses that lack the T8782C and C28144T mutations. However, inspection of Fig- ure 4 shows that clade B is connected to viruses lacking T8782C and C28144T by single mutational steps via other human iso- lates, so this explanation requires not only positing two markets with two progenitors differing by just two mutations, but also the exceedingly improbable evolution of one of these progenitors towards the other after it had jumped to humans." Actually no - simple to see how the mutations might have become fixed in the progression -I think the take-home is JB is dead set that Rambaut is wrong and actually B came before A. Because? [shared file(s): image.png] [2021-06-19 14:45:25] [Eddie Holmes] Is this something or nothing? I can't quite get my head around it. [2021-06-19 14:49:05] [Robert Garry] I think JB main point is they removed some SRA data re early cases - the data IMO - and maybe I can be shown the error of my ways - adds basically zero. It allows JB to complain about lack of transparency I guess. [2021-06-19 14:49:14] [Andrew Rambaut] [thread - ID: 2021-06-19 14:49:14] We already discussed this - the 'intermediates' are dubious and from February [2021-06-19 14:52:17] [Eddie Holmes] It's a weird sort of stream of consciousness paper. Very naughty to include an email from the unrelated pangolin study in there. Is that even legal? [2021-06-19 14:56:11] [Robert Garry] The WA1 tree - fig 4 and 6 looks fine to me - but me and trees so i really dunno. However the midle guangdong tree looks like :hankey: and forced just based on where WA1 lands, but again i'm no good here at all. [2021-06-19 14:58:30] [Eddie Holmes] The February part seems important.... [2021-06-19 15:02:15] [Robert Garry]