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Slack / Private Message Drop, p.947 [SLACK_001161] · slack_pm:msg:09854

Page text: p.947 · original PDF

Date
2021-06-19 14:44
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry
Topics
Natural origin / zoonotic spillover

Recipients on this medium are inferred from channel membership, not per-message addressing.

"The second explanation, which was proposed in a blog post by Garry (2021) and amplified by a popular podcast (Racaniello _et al._ 2021), is that there were multiple zoonoses from distinct markets, with the Huanan Seafood Market being the source of viruses in clade B, and some other market being the source of viruses that lack the T8782C and C28144T mutations. However, inspection of Fig- ure 4 shows that clade B is connected to viruses lacking T8782C and C28144T by single mutational steps via other human iso- lates, so this explanation requires not only positing two markets with two progenitors differing by just two mutations, but also the exceedingly improbableevolution of one of these progenitors towards the other after it had jumped to humans." Actually no - simple to see how the mutations might have become fixed in the progression -I think the take-home is JB is dead set that Rambautis wrong and actually B came before A. Because? [shared file(s): image.png]

Extracted statements

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StatementGradeAttributionStance
"The second explanation, which was proposed in a blog post by Garry (2021) and amplified by a popular podcast (Racaniello _et al._ 2021), is that there were multiple zoonoses from distinct markets, with the Huanan Seafood Market being the source of viruses in clade B, and some other market being the source of viruses that lack the T8782C and C28144T mutations. quoted / not their view quoted_external inside quotation marks asserts

In context

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  1. 2021-06-19 13:30 Robert F. Garry open
    @Kristian Andersen let me know if you want to have call later today/tomorrow before Tony/FrancisII - interested inyour thoughts
  2. 2021-06-19 14:08 Kristian G. Andersen open
    Yeah cutting my trip short for this and will be back tonight. Can we set up a call Sunday am with Andrew too?
  3. 2021-06-19 14:09 Kristian G. Andersen open
    I haven't looked at any of this yet
  4. 2021-06-19 14:44 Robert F. Garry
    "The second explanation, which was proposed in a blog post by Garry (2021) and amplified by a popular podcast (Racaniello _et al._ 2021), is that there were multiple zoonoses from distinct markets, with the Huanan Seafood Market being the source of viruses in clade B, and some other market being the source of viruses that lack the T8782C and C28144T mutations. However, inspection of Fig- ure 4 shows that clade B is connected to viruses lacking T8782C and C28144T by single mutational steps via other human iso- lates, so this explanation requires not only positing two markets with two progenitors differing by just two mutations, but also the exceedingly improbableevolution of one of these progenitors towards the other after it had jumped to humans." Actually no - simple to see how the mutations might have become fixed in the progression -I think the take-home is JB is dead set that Rambautis wrong and actually B came before A. Because? [shared file(s): image.png]
  5. 2021-06-19 14:45 Edward C. Holmes open
    Is this something or nothing? I can't quite get my head around it.
  6. 2021-06-19 14:49 Robert F. Garry open
    I think JB main point is they removed some SRA data re early cases - the data IMO - and maybe I can be shown the error of my ways - adds basically zero. It allows JB to complain about lack of transparency I guess.
  7. 2021-06-19 14:49 Andrew Rambaut open
    We already discussed this - the 'intermediates' are dubious and from February
  8. 2021-06-19 14:52 Edward C. Holmes open
    It's a weird sort of stream of consciousness paper. Very naughty to include an email from the unrelated pangolin study in there. Is that even legal?

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